Target
KinaseGauntlet Filters
Consensuspasses all criteria
0
AffinitypKd ≥ 7.0
0
Selectivity≥ 1.0 log vs off-target
0
Drug-likenessQED ≥ 0.50
0
Lipinski Ro5≤ 1 violation
0
Pass Rate
0/ 0 molecules clear the gauntlet
0%
Selectivity Panel
off-targetsKIT
P10721VEGFR2
P35968Selectivity = on-target pKd − max(off-target pKd). Higher is cleaner.
Ball & stick
Stick
Spacefill
Spin
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